The fall and winter seasons have higher incidence of upper respiratory infections and it is useful to know how to decrease your risk of infection, as well as how to best treat infections you have contracted. I will also discuss complications that may occur with viral respiratory infections, some of them life threatening, and reasonable approaches to treatment.
Why do we have more colds and flu in the fall and winter seasons? In 2007, researchers reported that the flu virus is more stable and stays in the air longer when air is cold and dry. Dr. Jeffrey Shaman, an atmospheric scientist at Oregon State University, and his colleagues have found more evidence that high humidity may help to stave off the flu virus. Additionally, in temperate regions both outdoor and indoor absolute humidity are at a minimum during winter months, conditions that favor influenza survival and transmission. Another reason viral illnesses occur more frequently during the cold weather months is the decrease in ultraviolet (UV) light from the sun. UV light rapidly inactivates viruses but is impractical for continuous indoor use, whereas natural sunlight can inactivate the virus outdoors, the problem being that UV radiation is very low at latitudes greater than about 34 degrees during the winter season.
Whoa, stop the presses – I just (12/24/2010) found this post by by Chris Masterjohn, http://www.cholesterol-and-health.com/cholesterol-blog.html, about our long-held beliefs regarding latitude, vitamin D and UV light. We may have had it wrong all this time. However, cold weather normally causes people to spend less time outdoors, and when they are out on a sunny day, their skin is covered by clothing. The end result is the same – we get less UV exposure during the winter.
A study in the American Journal of Public Health showed that both UV light and the wearing of face masks similar to those used in health care facilities decreased the incidence of influenza (Am J Public Health. 2007 April; 97(Supplement_1): S32–S37.) Cultural acceptance may encourage the use of facemasks (Asia) or discourage their use (United States). 
Prevention of Viral Infections
Public health authorities, such as the CDC (Centers for Disease Control and Prevention) list guidelines for preventing seasonal influenza, http://www.cdc.gov/flu/protect/preventing.htm. Here are their top recommendations, some of which I’ll discuss in more detail later.
1. CDC recommends a yearly flu vaccine as the first and most important step in protecting against flu viruses.
2. To stop the spread of virus:
Cover your nose and mouth with a tissue when you cough or sneeze. Throw the tissue in the trash after you use it.
Wash your hands often with soap and water. If soap and water are not available, use an alcohol-based hand rub. 
Avoid touching your eyes, nose and mouth. Germs spread this way.
Try to avoid close contact with sick people.
If you are sick with flu–like illness, CDC recommends that you stay home for at least 24 hours after your fever is gone except to get medical care or for other necessities. (Your fever should be gone without the use of a fever-reducing medicine.)
While sick, limit contact with others as much as possible to keep from infecting them.
3. Take antiviral flu drugs if your doctor recommends them:
If you get the flu, antiviral drugs can treat your illness.
Antiviral drugs are different from antibiotics. They are prescription medicines (pills, liquid or an inhaled powder) and are not available over-the-counter.
Antiviral drugs can make illness milder and shorten the time you are sick. They may also prevent serious flu complications.
It’s very important that antiviral drugs be used early (within the first 2 days of symptoms) to treat people who are very sick (such as those who are hospitalized) or people who are sick with flu symptoms and who are at increased risk of severe flu illness, such as pregnant women, young children, people 65 and older and people with certain chronic health conditions.
What I agree with and what I disagree with regarding CDC guidelines (If I disagree with a recommendation this does not mean I am suggesting you follow my opinion. This Blog does not recommend medical treatment, only your doctor can do that for you.)
1. I do not think influenza vaccinations are safe or effective. Pharmaceutical companies put their best guess forward as to which viruses will be active during the coming flu season; sometimes they are right and sometimes not. Flu vaccines have very little testing done for safety and effectiveness and the drug company has no liability if you are injured by their vaccine – thanks to the United States congress and rampant conflict of interest between drug companies and elected officials you have no legal rights after vaccine injury. How effective are flu vaccines? In an April 27, 2010 article on Minnesota Public Radio’s website they wrote: “If the main point of the nation’s influenza vaccination program is to reduce deaths from flu, then the program has failed, at least among people over 65. A growing body of research shows that because our immune systems age, flu vaccines don’t work as well in the elderly – the group of people most likely to die from flu-related causes.”
2. I agree with all of CDC’s suggestions to prevent the spread of viruses. The most important of these is hand washing or sanitizing.
3. Antiviral drugs are somewhat effective. The CDC states ” When used to prevent the flu, antiviral drugs are about 70% to 90% effective against susceptible viruses (i.e., viruses that are not resistant to the antiviral medication).” In order for a drug to be effective, according to FDA regulations, it only needs to show a significant difference from a placebo such as a sugar pill. There are also a number of side effects listed by CDC for the common antiviral drugs: http://www.cdc.gov/flu/protect/antiviral/sideeffects.htm
Prevention
So what have I found to work best and without side effects for cold and flu prevention? The three areas that are most important in protecting and bolstering the immune system are diet and nutrition, exercise, and stress reduction.
1. Optimize your vitamin D blood levels (the blood test is called 25-OH vitamin D) to 50-80 ng/mL. Safe upper limits for vitamin D3 (a fat-soluble nutrient) supplementation are in the range of 4,000-10,000 IU daily; I like to stay in the range of 4,000 IU daily to maintain good vitamin D levels. If you supplement only with vitamin D, and none of the other fat-soluble vitamins you risk causing a relative deficiency of vitamin A. My preferred supplement is Vitamin D3 Complete made by Allergy Research Group.
2. Wash your hands or sanitize them often after exposures.
3. Go for a walk or exercise outside unless the weather is too brutal. Viruses are much less concentrated where there are less people. Air out your house by opening the windows briefly during the winter; it helps dilute viruses much the same as going outside. Mild exercise does not really effect the duration of illness once an infection is acquired. However, exercise has the capacity to protect and even enhance the immune response. Experimental studies have shown that a regular exercise program of brisk walking can bolster many defenses of the immune system, including the antibody response and the natural killer (T cell) response.
Moderate exercise in sedentary subjects with naturally acquired URTI probably does not alter the overall severity and duration of the illness. Previously sedentary people who have acquired a URTI and have just initiated an exercise programme may continue to exercise. Br J Sports Med 2003;37:304-306
4. Decreasing sugar consumption to a minimum has been a long standing suggestion of nutritionaly minded doctors. The problem is, there is not a lot of evidence to directly support the concept that sugar supresses immunity. There are some old studies from 1977 showing that sugar consumption decreases neutrophil (a type of white blood cell) function. Excess sugar has a lot of negative impacts on health that are proven, so cutting back is always good.
5. Vitamin C is an important antioxidant. While many studies have shown that daily doses of vitamin C do little to protect you from the common cold, it can reduce the severity of colds. There are several controlled studies performed in populations of people working under heavy stress that have shown a significant protective effect of vitamin C in terms of common colds and pneumonia. Doses of 500-1000 mg daily are normally sufficient.
Treatments that work
My main treatment for viral URTI uses two products – at this time I’m not going into why the constituents of these two products work as antivirals.
1. Viracon, made by Vital Nutrients. Two capsules contain:
Sambucus nigra (Elderberry Fruit Extract 50:1) – 125mg
Scutellaria baicalensis 8:1 – 125mg
Propolis 70% – 100mg
Astragalus Root Extract 15:1 – 100mg
Isatis Root extract 15:1 – 100mg
Coptis chinensis Extract 10:1 – 50mg
Hypericum perf. Extract 0.3% – 50mg
Glycyrrhiza glabra (Licorice Root Extract) – 50mg
Zinc (citrate) – 5mg
2. Acute Immune, made by Mountain Peak Nutritionals: 2 capsules contain:
Vitamin A (as Palmitate) 10,000 IU
Vitamin C (as Poly C Ascorbate) 250 mg
Vitamin B6 (as Pyridoxyl-5-Phosphate) 25 mg
Magnesium (as Glycinate) 25 mg
Zinc (as Methionate) 10 mg
Echinacea Purpurea Extract (4% Phenolics) 350 mg
Olive Leaf Extract (18% Oleuropein) 350 mg
Mushroom Blend (Organic) 200 mg
Cordyceps Sinenis (Caterpillar)
Corilolus Versicolor (Turkey-Tail)
Grifola Frondosa (Maitake)
Letinula Edodes (Shiitake)
Schizophyllum Commune (Split Gill)
Tramella Fuciformis (White Wood-Ear)
DMG (as Dimethylglycine) 100 mg
Garlic Extract (10 % Allicin) 75 mg
Ginger Root Extract (5% Gingerol) 50 mg
Grapefruit Seed Extract (20:1) 50 mg
Beta 1,3 Glucan (60%) 50 mg
Oregano Extract (4:1) 50 mg
Quercetin 50 mg
Cayenne (as Capsicum) (90 HU/gm) 20 mg
I have people start these two products simultaneously at the onset of symptoms; if they feel any symptoms, even if they are not sure, they should start taking the two products in the doses I recommend. In the great majority of cases, over 90% in my experience, the URTI will be limited to about 24-48 hours duration and the symptoms will be mild. In cases where it does not prevent the development of the illness, the products will still improve the course and speed recovery.
Another good product is made by Barlow Herbal Specialties, LDM-100, an extract of Lomatium dissectum is a very effective antiviral. Use of extracts containing the resin (and possibly the coumarins) of Lomatium can, in some people, cause a whole-body rash. The safety of lomatium during pregnancy and lactation is unknown and is therefore not recommended.
I will often have people try 2-3 homeopathic remedies as well; if the remedy is going to work for a person they may experience the elimination of symptoms within 15 minutes of taking the correct one. The remedies are Eupatorium perfolitatum, Gelsemium or Oscillococcinum. These homeopathic medicines may be taken at first onset of symptoms and may be repeated up to 5 doses. The remedy that works for me personally is Eupatorium; I can awaken at night feverish and with aches and a sore throat, and a single dose can alleviate all my symptoms within about 15-30 minutes. Experiment with the common flu remedies and find the one that works for you, it is definitely worthwhile. You can check out the information for common flu/cold remedies here: http://www.holisticonline.com/remedies/flu/flu_homeopathy.htm
What if I have a URTI and need to shorten its course?
Many of us find that we have a business trip coming up in a few days and we are laid low with a miserable URTI. How can we shorten the course enough to feel better and undertake air travel safely?* Start taking Viracon and Acute Immune immediately. Then find a doctor who has expertise in intravenous (IV) nutrient therapy who can safely administer IV vitamin C such as myself. If you do not know doctors in your geographical area who offer IV nutrient treatments, your first best search tool is to go to http://www.acamnet.org/ and locate an ACAM physician by entering your Zip code. For the treatment of acute viral illness, IV vitamin C is one of the most effective nutrients/drugs available. After treating many patients with acute viral disease, I find that 2-6 treatments will resolve the illness. There are some genetic issues that need to be addressed before a person can receive IV vitamin C in doses greater than 10-15 grams; the most important of these is G6PD deficiency, but there is also risk in people with hemoglobin S disease. A blood test for G6PD levels needs to be completed prior to administering high dose vitamin C, since people with G6PD deficiency will most likely suffer red blood cell hemolysis, which can result in death. People who have normal G6PD levels, and those who do not have hemoglobin S disease, tolerate high dose (up to 100 grams) IV vitamin C well. To reiterate, make sure your doctor is experienced in high dose IV vitamin C treatments.
*It is not advised to travel by air when you have serious sinus and eustation tube blockage secondary to heavy mucus production caused by a URTI.
Cytokine storms
Not many people have heard about cytokine storms, but many have heard about the deaths caused by the bird flu (H5N1 virus) or swine flu (H1N1 virus). It is not uncommon for the elderly to develop pneumonia after a lingering flu-like illness, but it is much less common for younger people to die from the effects of influenza. A cytokine storm occurs when the body’s immune system overreacts to an intruder, such as a virus, by producing high levels of cytokines, which are signaling chemicals that help mobilize immune cells responsible for removing infectious agents from the body. When too many cytokines are produced, they may stimulate an inflammatory response in which the accumulation of immune cells and fluid at the site of infection may prevent affected tissues and organs such as the lungs from functioning properly (acute respiratory distress syndrome, ARDS) which can lead to death. Cytokine storms associated with ARDS have been treated by forcing progression of the inflammatory process into its recovery phase with anti-inflammatory treatments.
Perhaps the most effective treatment for cytokine storm is not a drug, it is IV vitamin C. There was a widely reported case from New Zealand in 2009, where a farmer contracted influenza and developed a cytokine storm. He was hospitalized, put on life support after his lungs stopped functioning, and was dying. His family obtained a court order that demanded the hospital administer IV vitamin C. He recovered, but only over the protest of the doctors who were forced to give the treatment. Sufficient doses need to be used for sufficient time in order for vitamin C to be effective.
Vitamin D also helps modulate the effects of cytokine storms, as do curcumin and fish oil; their effect is not near as strong as IV vitamin C.